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血清分泌型卷曲相关蛋白5与早期糖尿病肾病的相关性研究

来自:金沙娱城总站3777  编辑:刘云涛 简磊 潘敬芳|点击数:|2016-03-06

 

    【摘要】  目的   探讨早期糖尿病慢性肾脏疾病(CKD)患者血清分泌型卷曲相关蛋白5 (SFRP5)与早期糖尿病肾病(EDN)的相关性。  方法   选择新诊断单纯 T2DM 患者43 例、EDN患者42例,另选择健康体检者(NC ) 42名。 ELISA测定空腹血清SFRP5水平。  结果  3组血清SFRP5水平依次为: NC组(5.02±0.69)μg/L vs T2DM组(4.37±0.53)μg/L vs  EDN组(3.76±0.49)μg/L(P<0.05或P<0.01)。血清SFRP5水平与胰岛素抵抗指数(HOMA-IR)、FIns、FPG、HbA1c、BMI、IL-6、TG、TNF-α、UAER、尿白蛋白/肌酐(UAlb/Cr)、病程呈负相关(r=-0.573、-0.522、-0.589、-0.601、-0.467、-0.515、-0.542、-0.647、-0.592、-0.638、-0.553,P<0.05或P<0.01),与SOD呈正相关(r=0.603, P<0.01)。多元逐步回归分析显示,HOMA-IR、TNF-α、UAlb/Cr是SFRP5的独立影响因素。  论   EDN患者血清SFRP5水平降低,血清SFRP5 与EDN 的严重程度相关。

   【关键词】 分泌型卷曲相关蛋白5;糖尿病,2型;糖尿病肾病 

  【Abstract】  Objective  To explore the association between serum secreted frizzled-related protein 5(SFRP5) and early type 2 diabetic nephropathy(EDN).  Methods  A total of 127 subjects were enrolled in this study and divided into three groups: patients with newly diagnosed type 2 diabetesT2DM group, n=43), patients with early diabetic nephropathyEDN group, n=42,and healthy subjects with normal glucose toleranceNC group, n=42.Serum SFRP5 was measured by ELISA.  Results   The serum SFRP5 were(5.02±0.69)μg/L, (4.37±0.53)μg/L, and (3.76±0.49)μg/L in NC, T2DM and EDN group respectively  (P0.05 or P0.01). (2) SFRP5 were negatively correlated with HOMA-IRFIns, FPGHbA1c, BMI, IL-6, TG,TNF-α,UAER,UAlb/Cr, and duration of diabetesr=-0.573,-0.522,-0.589,-0.601,-0.467,-0.515,-0.542,-0.647,-0.592,-0.638,-0.553P0.05 or P0.01)and positively correlated with SODr=0.603P0.01). Multiple linear regression analysis showed that HOMA-IR, TNF-α and UAlb/Cr were independent influencing factors for SFRP5.  Conclusion  Serum SFRP5 is decreased in patients with EDN. Serum SFRP5 is associated with severity of DN.

  Key words】  Secreted frizzled-related protein 5(SFRP5)Diabetes mellitustype 2Diabetic nephropathy(DN)

 

上一篇:2型糖尿病患者蛋白尿与振动感觉阈值关系的研究 下一篇:血清糖化终末产物类物质与糖尿病慢性肾脏疾病的关系

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