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2型糖尿病患者合并低T3综合征与糖化血红蛋白和胰岛β细胞功能相关性的研究

来自:金沙娱城总站3777  编辑:钟兴 徐小群 杜益君等|点击数:|2016-03-06

    

     【摘要】  目的   探讨住院T2DM患者合并低T3综合征发生率、临床特点和相关危险因素。 方法   249例T2DM患者根据甲状腺功能分为单纯T2DM(T2DM)组和T2DM合并低T3综合征(T2DM-LT3)组。检测HbA1c、FPG、FC-P、总三碘甲状腺原氨酸(TT3)、血清总甲状腺素(TT4)和促甲状腺激素(TSH)等指标。  结果   T2DM-LT3组FC-P和HOMA-β低于T2DM组,糖尿病酮症发生率、HbA1c和FPG高于T2DM组(P<0.05)。Pearson相关分析显示,TT3与HOMA-β和FCP呈正相关(r=0.192、0.174,P <0.01);与HbA1c、FPG和糖尿病酮症呈负相关(r =-0.319、-0.222、-0.202,P<0.01)。Logistic回归分析显示, FC-P、TG和HbA1c是低T3综合征的危险因素。  结论   T2DM患者中低T3综合征可能与血糖控制不佳和胰岛功能受损相关。
   【关键词】  低T3综合征;糖尿病,2型;胰岛功能指数;糖化血红蛋白 

  Association analysis between low T3 syndrome and HbA1c, HOMA-β in patients with type 2 diabetes

    【Abstract】  Objective To investigate the prevalence and clinical characteristics of low T3 syndrome in hospitalized patients with type 2 diabetes.  Methods  A total of 249 type 2 diabetic patients were enrolled in this study and divided into two groups according to their thyroid function: T2DM with normal thyroid function (T2DM group) and T2DM with low T3 syndrome (T2DM-LT3 group). HbA1cFPG, FC-P, TT3, TT4 and TSH were measured in all subjects.  Results  FC-P and HOMA-β were significantly lower in T2DM-LT3 group than in T2DM group. The prevalence of diabetic ketosisHbA1c and FPG were significantly higher in T2DM-LT3 group than in T2DM group (P0.05).Pearson analysis showed that TT3 was positively correlated with HOMA-βr=0.192P =0.000and FCPr=0.174P=0.006, and negatively correlated with HbA1c (r=0.319P=0.000), FPG (r=0.222P=0.000), and incidence of diabetic ketosis (r=0.202P =0.001). Logistic regression analysis showed that FCP, TG, and HbA1c were independent risk factors for low T3 syndrome.  Conclusion  Low T3 syndrome may be associated with poor glycaemic control and damage of islet β cell in patients with type 2 diabetes.

    【Key words】 Low T3 syndrome; Diabetes mellitus, type 2; Islet β cell function; Hemoglobin (A1c)

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